In this work, we present an innovative method which enables to solve fundamental limitations affecting graphene-based chemi-sensors operating under environmental conditions, namely the lack of signal saturation and the scarce recovery after the detection step. The method, which exploits the differential current instead of the current itself, is validated by applying it on different devices having an exposed area equal to 512 pm2. The analysis is performed by adopting nitrogen dioxide (NO2) as target gas in the range from 0.12 ppm to 1.5 ppm. The approach reliability is further confirmed by performing sensing tests towards NO2 with the relative humidity set at two different levels, 30% and 50%. © 2017 IEEE.