The present paper proposes and preliminarily discusses the possibility to produce thermal fluxes of sufficient intensity for BNCT (explanted liver and skin melanoma) and BNCS (rheumatoid arthritis), using commercial cyclotrons conceived for radioisotopes production. Application of BNCT to the treatment of liver and melanoma require a thermal neutron fluence of about 5 10E12 cm-2, that correspond to a thermal fluence rate of the order of about 1.5 10E09 cm-2 s-1 for one hour irradiation. In the case of BNCS about 5 10E11 cm-2 are required, that correspond to a thermal fluence rate of the order of about 10E9 cm-2 s-1 for 10 minutes irradiation. Purpose of this preliminary study is to verify the current requirements to obtain the needed thermal fluence rate. This study is necessary before proceeding to the optimisation of the moderating structure and to the experimental tests.

A Cyclotron Based Solution for a BNCT Source

Rossi, S.
2001-02-17

Abstract

The present paper proposes and preliminarily discusses the possibility to produce thermal fluxes of sufficient intensity for BNCT (explanted liver and skin melanoma) and BNCS (rheumatoid arthritis), using commercial cyclotrons conceived for radioisotopes production. Application of BNCT to the treatment of liver and melanoma require a thermal neutron fluence of about 5 10E12 cm-2, that correspond to a thermal fluence rate of the order of about 1.5 10E09 cm-2 s-1 for one hour irradiation. In the case of BNCS about 5 10E11 cm-2 are required, that correspond to a thermal fluence rate of the order of about 10E9 cm-2 s-1 for 10 minutes irradiation. Purpose of this preliminary study is to verify the current requirements to obtain the needed thermal fluence rate. This study is necessary before proceeding to the optimisation of the moderating structure and to the experimental tests.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.12079/4334
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