A simple prediction method for the bipolar pulse cancellation effect is proposed, based on analysis of single-cell transmembrane potential frequency spectra for a variety of unipolar and bipolar input signals in the nanosecond and microsecond time scales. Our evaluations are in good agreement with experimental results for electropermeabilization-induced Ca2+ influx using 300 ns, 750 kV/m pulses. © 2017 IEEE.

Frequency spectra of induced transmembrane potential correlate with nanosecond bipolar pulse cancellation of electropermeabilization

Merla, C.
2017

Abstract

A simple prediction method for the bipolar pulse cancellation effect is proposed, based on analysis of single-cell transmembrane potential frequency spectra for a variety of unipolar and bipolar input signals in the nanosecond and microsecond time scales. Our evaluations are in good agreement with experimental results for electropermeabilization-induced Ca2+ influx using 300 ns, 750 kV/m pulses. © 2017 IEEE.
9781509050529
bipolar electric pulses;spectral analysis;microdosimetry;cancellation effect;Ca2+ influx
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.12079/4969
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