Transparent adaptive façade components can improve the energy performance and the indoor environmental quality of buildings. Nevertheless, their utilization is not widespread, due also to the lack of a robust methodology to comprehensively evaluate their potentialities and find out their most suitable applications. The present paper introduces a novel methodology to characterize the behavior of a transparent adaptive façade component, a thermo-chromic glazing, and predict its effects, through numerical simulations, on energy performance and visual comfort aspects. An experimental characterization on the thermo-chromic glazing was performed to determine its optical properties at the variation of its surface temperature. The component was found to be able to switch its visible transmittance between 0.71 and 0.13, and its solar transmittance between 0.65 and 0.28. The experimental results were used to feed the numerical model created on purpose to describe the adaptive behavior of the component. Finally, a numerical simulation campaign was performed to assess the effects of the thermo-chromic glazing on energy and visual comfort aspects of an enclosed office located in Turin. It was found that the thermo-chromic glazing reduced the overall energy performance compared to a static selective glazing, but it allows improving the visual comfort conditions within the space considered.