Gravity-induced deformations due to Rock-Mass Creep (RMC) affect the carbonate Peschiera Springs slope (Italy) which hosts the most important drainage plant for the Rome’s water supply. This water resource is due to a major regional karst aquifer with an average discharge exceeding 18 m3/s. The interaction of the RMC with the karst ground water seepage is responsible for underground failures, including cave collapses which generally occur very close to the spring area. On September 2008, an accelerometric array was installed within the tunnels of the drainage plant for integrating a pre-existing stress-strain monitoring system. The integrated monitoring system provided many data on: i) continuous deformations due to the RMC which affects the slope; ii) microseismicity due to the underground failures occurring within the slope; ii) underground failures and rock-mass deformations induced by earthquakes. The up to now collected data, were fundamental for deriving an alarm system devoted to the drainage plant management and based on some characteristic parameters of the seismic records. This alarm system provides three possible levels of alarm, which can be independently reached in the different sectors of the drainage plant: the “ordinary” level; the “alert” level and the “emergency” level. Some recently occurred events of underground failures made it possible to experience the reliability of the adopted alarm system. © 2013 Taylor & Francis Group, London.