DEMO initial conceptual design studies are being conducted in Europe as part of the European Union Roadmap to Fusion Electricity, which aims to demonstrate the feasibility of electricity produced by nuclear fusion reactors around the middle of this century. The aim of this paper is to provide an overview of the DEMO project, highlighting its main characteristics and challenges in terms of design, integration, and operation. Particular emphasis is given on some important systems of the Balance of Plant (BoP), such as the primary heat transfer systems, the related power conversion systems, and the electrical power plant. The relevance of such systems is due to the need of a continuous reanalysis at any significant design change because of their huge dimensions, technical complexity, and strong impact on design integration, maintenance, and safety. © 2017 IEEE.