Proton therapy uses proton beams to destroy cancer cells. Since the energy deposition of protons peaks at the end of the trajectory (Bragg peak), healthy tissues close to the target are partially spared. In clinical practice, beams of different energies are composed to obtain a broadened peak (SOBP, Spread Out Bragg Peak) to treat the entire lesion region in a uniform manner. In the framework of the TOP-IMPLART project (linear accelerator for proton therapy under construction at ENEA-Frascati), we present a semi-analytical method that allows to optimize SOBP uniformity for two different energy-modulation techniques, passive and active.

Optimization of the theoretical dose distribution in the “Spread out Bragg Peak” (SOBP) region in proton therapy by means of semi-analytical techniques

Nichelatti E.;Ronsivalle C.;Picardi L.;Montereali R. M.
2021

Abstract

Proton therapy uses proton beams to destroy cancer cells. Since the energy deposition of protons peaks at the end of the trajectory (Bragg peak), healthy tissues close to the target are partially spared. In clinical practice, beams of different energies are composed to obtain a broadened peak (SOBP, Spread Out Bragg Peak) to treat the entire lesion region in a uniform manner. In the framework of the TOP-IMPLART project (linear accelerator for proton therapy under construction at ENEA-Frascati), we present a semi-analytical method that allows to optimize SOBP uniformity for two different energy-modulation techniques, passive and active.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12079/64069
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