Detailed mapping of geomorphological and biological sea-level markers around the Capo Vaticano promontory (western Calabria, Italy), has documented the occurrence of four Holocene paleo-shorelines raised at different altitudes. The uppermost shoreline (PS1) is represented by a deeply eroded fossiliferous beach deposit, reaching an elevation of ~2.2. m above the present sea-level, and by a notch whose roof is at ~2.3. m. The subjacent shoreline PS2 is found at an elevation of ~1.8. m and is represented by a Dendropoma rim, a barnacle band and by a wave-cut platform. Shoreline PS3 includes remnants of vermetid concretions, a barnacle band, a notch and a marine deposit, and reaches an elevation of ~1.4. m. The lowermost paleo-shoreline (PS4) includes a wave-cut platform and a notch and reaches an elevation of ~0.8. m. Radiocarbon dating of material from individual paleo-shorelines points to an average uplift rate of 1.2-1.4. mm/yr in the last ~6. ka at Capo Vaticano. Our data suggest that Holocene uplift was asymmetric, with a greater magnitude in the south-west sector of the promontory, in a manner similar to the long-term deformation attested by Pleistocene terraces. The larger uplift in the south-western sector is possibly related to the additional contribution, onto a large-wavelength regional signal, of co-seismic deformation events, which are not registered to the north-east. We have recognized four co-seismic uplift events at 5.7-5.4. ka, 3.9-3.5. ka, ~1.9. ka and <1.8. ka ago, superposed on a regional uplift that in the area, is occurring at a rate of ~1. mm/yr. Our findings places new constrains on the recent activity of border faults south of the peninsula and on the location of the seismogenic source the 1905 destructive earthquake.