The extraordinary advancement in developing highly efficient packing materials for liquid chromatography (LC) has only partly touched chiral separations due, in part, to practical problems in synthesis and functionalization of sub-2-μm particles with chiral selectors, and, in part, to the lack of clear understanding of mass-transfer mechanisms in chiral chromatography. However, there is increasing demand for ultrafast chiral separations, mainly from fine chemical and pharmaceutical companies.This review revisits the most important achievements in enantioselective ultra-high-performance LC (eUHPLC) by focusing, in particular, on brush-type chiral stationary phases, as they are the most promising materials for transition from traditional high-performance LC (HPLC) to ultra-high-speed and ultra-high-pressure regimes.We also attempt to predict possible future trends and solutions that will contribute to making eUHPLC a routine technique in analytical laboratories.

Enantioseparation by ultra-high-performance liquid chromatography

Guzzinati, R.
2014

Abstract

The extraordinary advancement in developing highly efficient packing materials for liquid chromatography (LC) has only partly touched chiral separations due, in part, to practical problems in synthesis and functionalization of sub-2-μm particles with chiral selectors, and, in part, to the lack of clear understanding of mass-transfer mechanisms in chiral chromatography. However, there is increasing demand for ultrafast chiral separations, mainly from fine chemical and pharmaceutical companies.This review revisits the most important achievements in enantioselective ultra-high-performance LC (eUHPLC) by focusing, in particular, on brush-type chiral stationary phases, as they are the most promising materials for transition from traditional high-performance LC (HPLC) to ultra-high-speed and ultra-high-pressure regimes.We also attempt to predict possible future trends and solutions that will contribute to making eUHPLC a routine technique in analytical laboratories.
Enantioselectivity;Brush-type chiral selector;Chiral stationary phase;Enantioselective ultra-high-performance supercritical fluid chromatography (eUHPSFC);Chiral UHPLC;High-throughput chiral analysis;Enantioselectivity ultra-high-performance liquid chromatography (eUHPLC);Mass transfer;Sub-2-μm particle;Stereodynamic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12079/827
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